Dr. Gregory House is devoid of bedside manner and wouldn't even talk to his patients if he could get away with it. Dealing with his own constant physical pain and ignoring his pain killing addiction, he uses his cane to punctuate his acerbic, brutally honest demeanor. House and his team deal with unusual medical mysteries.

An elite team of medical and scientific specialists race to save a top government scientist who is suffering from blood clot on the brain. Their mission is to be reduced along with their submarine-like craft to microscope size, enter the bloodstream of the ailing scientist, and journey to the brain to perform an emergency procedure. With only sixty minutes to complete their mission, the scientists find themselves fighting off an attack by white corpuscles,...

Reunite with the perplexing and prickly Dr. Gregory House as he tackles impossible cases while putting a new staff of potential team members through the medical wringer with his trademark sarcasm and irreverent bedside manner.