Despite his overwhelming fear of interacting with people, Christopher, a mathematically-gifted, autistic fifteen-year-old boy, decides to investigate the murder of a neighbor's dog and uncovers secret information about his mother. Christopher John Francis Boone knows all the countries of the world and their capitals and every prime number up to 7,057. He relates well to animals but has no understanding of human emotions. He cannot stand to be touched....

An autistic teenager retreats into the world of online gaming, to escape bullying at school. With the help of a friend he meets online, he devises a plan to confront the bullies.

Adam is a handsome but intriguing young man who has Asperger's syndrome and has led a sheltered existence. Then he meets his new neighbor, Beth. She is a beautiful, cosmopolitan young woman who pulls him into the outside world, with funny, touching and entirely unexpected results. Their implausible and enigmatic relationship reveals just how far two people from different realities can stretch in search of an extraordinary connection.

Rizwan, an Indian man with a unique way of looking at the world, moves to San Francisco and meets a vivacious single mother named Mandira. They form a special bond and fall in love against all odds, but fate and tragedy conspire to tear them apart. That's when Rizwan embarks on a remarkable journey across America to win back the love of his life.