Chloe is a pampered Beverly Hills chihuahua who, while on vacation in Mexico with her owner's niece, Rachel, gets lost. She must rely on her new friends to help her get back home before she is caught by a dognapper who wants to ransom her. In the meantime, Papi, a male chihuahua who is in love with Chloe goes in pursuit of her. Papi's owner is a handsome young gardener for Rachel's aunt Viv. He slowly develops a romantic interest in Rachel. Chloe...

Puppy mayhem turns the lives of newlywed Chihuahua parents Papi and Chloe upside down when their rambunctious, mischievous puppies present one challenge after another. But when their human owners end up in trouble, the tiny pups will stop at nothing to save them, because in good times and hard times, the family always sticks together.